The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics
Se probó la respuesta in vitro de Necator americanus a 20 antihelmínticos. Con valores de EC50 desde 0 .0002 hasta 0 .0007 mg/L, los antihelmínticos de espectro amplio afectaron a machos, hembras y estadíos libres. Ciertas drogas emetine, praziquantel y suramin) afectaron selectivamente a los grupos...
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| Formato: | Online |
| Idioma: | eng |
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Universidad de Costa Rica
1987
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| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/rbt/article/view/24148 |
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RBT241482022-05-19T18:27:47Z The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics Kumar, Sanjeev The in vitro response of adults (males and females) and free-living stages of Necator americanus one of the human hookworms, to a wide variety of 20 broad and narrow spectrum anthelmintics was tested. Almost all the broad spectrum anthelmintics influenced males, females and free-living stages at different levels and showed good activity with EC50 values varying from about 0.0002 and 0.0007 mg/l for pyrantel pamoate and tricofenol piperazine respectively to about 8.47 and 7.6 mg/l for morantel tartrate and amoscanate respectively. Certain drugs (emetine, praziquantel and suramin) exerted their effect either on male or female or free-living stages at 10.0 mg/l level. It is concluded that either sex or life-cycle stage alone may not be an effective criteria for screening of anthelmintics which have been employed at large; and females of nematodes (in particular those of N. americanus) should be taken into account for proposing EC50 as they were found to require relatively highest EC50 level in almost all the instances studied presently. Se probó la respuesta in vitro de Necator americanus a 20 antihelmínticos. Con valores de EC50 desde 0 .0002 hasta 0 .0007 mg/L, los antihelmínticos de espectro amplio afectaron a machos, hembras y estadíos libres. Ciertas drogas emetine, praziquantel y suramin) afectaron selectivamente a los grupos mencionados al nivel de 10.0 mg/L. Las hembras requirieron mayores niveles de tratamiento, lo que tiene importantes implicaciones en la aplicación de antihelmínticos. Universidad de Costa Rica 1987-06-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article application/pdf https://revistas.ucr.ac.cr/index.php/rbt/article/view/24148 Revista de Biología Tropical; Vol. 35 No. 1 (1987): Volume 35 – Regular number 1 – June 1987; 73–76 Revista de Biología Tropical; Vol. 35 Núm. 1 (1987): Volumen 35 – Número regular 1 – Junio 1987; 73–76 Revista Biología Tropical; Vol. 35 N.º 1 (1987): Volume 35 – Regular number 1 – June 1987; 73–76 2215-2075 0034-7744 10.15517/rbt.v35i1 eng https://revistas.ucr.ac.cr/index.php/rbt/article/view/24148/24268 Copyright (c) 1987 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0 |
| institution |
Universidad de Costa Rica |
| collection |
Revista de Biología Tropical |
| language |
eng |
| format |
Online |
| author |
Kumar, Sanjeev |
| spellingShingle |
Kumar, Sanjeev The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| author_facet |
Kumar, Sanjeev |
| author_sort |
Kumar, Sanjeev |
| description |
Se probó la respuesta in vitro de Necator americanus a 20 antihelmínticos. Con valores de EC50 desde 0 .0002 hasta 0 .0007 mg/L, los antihelmínticos de espectro amplio afectaron a machos, hembras y estadíos libres. Ciertas drogas emetine, praziquantel y suramin) afectaron selectivamente a los grupos mencionados al nivel de 10.0 mg/L. Las hembras requirieron mayores niveles de tratamiento, lo que tiene importantes implicaciones en la aplicación de antihelmínticos. |
| title |
The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| title_short |
The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| title_full |
The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| title_fullStr |
The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| title_full_unstemmed |
The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| title_sort |
response of adult and free-living stages of necator americanus, in vitro, to anthelmintics |
| title_alt |
The response of adult and free-living stages of Necator americanus, in vitro, to anthelmintics |
| publisher |
Universidad de Costa Rica |
| publishDate |
1987 |
| url |
https://revistas.ucr.ac.cr/index.php/rbt/article/view/24148 |
| work_keys_str_mv |
AT kumarsanjeev theresponseofadultandfreelivingstagesofnecatoramericanusinvitrotoanthelmintics AT kumarsanjeev responseofadultandfreelivingstagesofnecatoramericanusinvitrotoanthelmintics |
| _version_ |
1810114946956001280 |