Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage
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Universidad Nacional, Costa Rica
2019
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| Acceso en línea: | https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/13268 |
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VETERINARIA132682021-11-26T05:13:34Z Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage Hacia la regeneración funcional de quizás el tejido más difícil del cuerpo: el cartílago articular van Weeren, P. R. Regenerative medicine aims at restoring or improving lost or affected functions of the body by stimulating the inherent healing capacity of tissues. The central paradigm of tissue engineering is that such repair is facilitated and enhanced using several approaches that may range from application of biologically active products (such as growth factor containing platelet rich plasma (PRP) or stem cells from a variety of sources) to the use of biofabricated implants. In all cases the aim is that in the end the body’s own healing capacity will result in the production of tissues that are identical to or at least functionally equivalent to the original tissues of which the function has been (partially) lost. In the case of the use of biofabricated implants, these are meant as temporary scaffolds that will stimulate the body’s own cells through a variety of cues but are destined to finally degrade and be replaced by newly made tissue. Ideally, this is a well-balanced gradual process in which there is a match between the disappearance (and loss of biological effect) of the engineered tissues and the formation (and increased biological effect) of the native tissues that replace the implant.There are many examples of successful applications of this theory, e.g. in the areas of bladder reconstruction (Londono & Badylak 2015). However, recently, it has become clear that this concept (and hence the paradigm) does not hold for articular cartilage because the collagen network, which is crucial for the biomechanical functions of articular cartilage, will, once damaged, not be reconstituted to any degree in mature individuals (Heinemeier et al. 2016). For this reason, a paradigm shift is necessary in the field of regenerative medicine of articular cartilage and attempts at tissue engineering in this field will have to be redirected. There are in principle two ways to achieve such a paradigm shift: either by recreating the tissue homeostatic and (epi)genetic environment as present in fetuses and young, growing, individuals in which remodeling of the collagen network is still possible, or by adopting Nature’s approach in the mature individual, i.e. by creating a life-long persisting, immutable structural component of articular cartilage. Both ways face considerable challenges before they can become reality. Universidad Nacional, Costa Rica 2019-12-27 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion texto Documentos application/pdf text/html application/epub+zip https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/13268 10.15359/rcv.37-3.3 Ciencias Veterinarias; Vol. 37 No. 3 (2019): Suplement: First Symposium on Regenerative Medicine and Nanotechnology; 11-12 Ciencias Veterinarias; Vol. 37 Núm. 3 (2019): Suplemento: Simposio de Medicina Regenerativa y Nanotecnología; 11-12 2215-4507 0250-5649 eng https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/13268/18595 https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/13268/18674 https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/13268/18687 Copyright (c) 2019 Revista Ciencias Veterinarias |
| institution |
Universidad Nacional de Costa Rica |
| collection |
Ciencias Veterinarias |
| language |
eng |
| format |
Online |
| author |
van Weeren, P. R. |
| spellingShingle |
van Weeren, P. R. Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| author_facet |
van Weeren, P. R. |
| author_sort |
van Weeren, P. R. |
| title |
Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| title_short |
Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| title_full |
Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| title_fullStr |
Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| title_full_unstemmed |
Towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| title_sort |
towards functional regeneration of perhaps the most difficult tissue in the body: articular cartilage |
| title_alt |
Hacia la regeneración funcional de quizás el tejido más difícil del cuerpo: el cartílago articular |
| publisher |
Universidad Nacional, Costa Rica |
| publishDate |
2019 |
| url |
https://www.revistas.una.ac.cr/index.php/veterinaria/article/view/13268 |
| work_keys_str_mv |
AT vanweerenpr towardsfunctionalregenerationofperhapsthemostdifficulttissueinthebodyarticularcartilage AT vanweerenpr hacialaregeneracionfuncionaldequizaseltejidomasdificildelcuerpoelcartilagoarticular |
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