Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae)
| Autores principales: | , , , , , , , |
|---|---|
| Formato: | Online |
| Idioma: | eng |
| Publicado: |
Universidad de Costa Rica
2018
|
| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/rbt/article/view/33412 |
| id |
RBT33412 |
|---|---|
| record_format |
ojs |
| spelling |
RBT334122022-06-09T18:14:13Z Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) Rodríguez-Chaves, Daniela Bagnarello-Madrigal, Vanessa Alpizar-Cordero, Javier Calvo-Vargas, Alonso Cordero-Villalobos, Maribel Chinchilla-Carmona, Misael Valerio-Campos, Idalia Sánchez Porras, Ronald Leishmania Leishmaniasis Piper auritum phytochemical screening treatment. Anti-Leishmania (Trypanosomatidae) activity of trans-Z-α-bisabolene epoxide and isolation of safrole, in fruits of Piper auritum (Piperaceae). The leishmaniosis disease incidence is high in tropical regions, and its current treatment has shown severe secondary effects. Considering this problem, many studies have focused on plants, looking for chemical components that have anti-leishmanial activity, and are free of adverse effects for human beings. The purpose of this work was to find a chemical component with this kind of activity in Piper auritum. In a phytochemical screening of this plant, we found some cumarins, terpens, triterpens and reducing sugars; and later, we identified the components trans-Z-α-bisabolene epoxide and Safrol. The first component presented a CI50 of 50.0 µg/mL of anti-Leishmania activity. The Safrol, which is the major component of the essential oils of this plant, did not show antiparasitic activity. These results are discussed considering treatment of leishmaniasis. Rev. Biol. Trop. 66(2): 826-835. Epub 2018 June 01. Universidad de Costa Rica 2018-06-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article application/pdf text/html https://revistas.ucr.ac.cr/index.php/rbt/article/view/33412 10.15517/rbt.v66i2.33412 Revista de Biología Tropical; Vol. 66 No. 2 (2018): Volume 66 – Regular number 2 – June 2018; 826–835 Revista de Biología Tropical; Vol. 66 Núm. 2 (2018): Volumen 66 – Número regular 2 – Junio 2018; 826–835 Revista Biología Tropical; Vol. 66 N.º 2 (2018): Volume 66 – Regular number 2 – June 2018; 826–835 2215-2075 0034-7744 10.15517/rbt.v66i2 eng https://revistas.ucr.ac.cr/index.php/rbt/article/view/33412/32884 https://revistas.ucr.ac.cr/index.php/rbt/article/view/33412/32921 Copyright (c) 2018 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0 |
| institution |
Universidad de Costa Rica |
| collection |
Revista de Biología Tropical |
| language |
eng |
| format |
Online |
| author |
Rodríguez-Chaves, Daniela Bagnarello-Madrigal, Vanessa Alpizar-Cordero, Javier Calvo-Vargas, Alonso Cordero-Villalobos, Maribel Chinchilla-Carmona, Misael Valerio-Campos, Idalia Sánchez Porras, Ronald |
| spellingShingle |
Rodríguez-Chaves, Daniela Bagnarello-Madrigal, Vanessa Alpizar-Cordero, Javier Calvo-Vargas, Alonso Cordero-Villalobos, Maribel Chinchilla-Carmona, Misael Valerio-Campos, Idalia Sánchez Porras, Ronald Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) |
| author_facet |
Rodríguez-Chaves, Daniela Bagnarello-Madrigal, Vanessa Alpizar-Cordero, Javier Calvo-Vargas, Alonso Cordero-Villalobos, Maribel Chinchilla-Carmona, Misael Valerio-Campos, Idalia Sánchez Porras, Ronald |
| author_sort |
Rodríguez-Chaves, Daniela |
| title |
Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) |
| title_short |
Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) |
| title_full |
Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) |
| title_fullStr |
Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) |
| title_full_unstemmed |
Actividad in vitro anti-Leishmania (Trypanosomatidae) del epóxido trans-Z-α-bisaboleno y del Safrol, en frutos de Piper auritum (Piperaceae) |
| title_sort |
actividad in vitro anti-leishmania (trypanosomatidae) del epóxido trans-z-α-bisaboleno y del safrol, en frutos de piper auritum (piperaceae) |
| publisher |
Universidad de Costa Rica |
| publishDate |
2018 |
| url |
https://revistas.ucr.ac.cr/index.php/rbt/article/view/33412 |
| work_keys_str_mv |
AT rodriguezchavesdaniela actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT bagnarellomadrigalvanessa actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT alpizarcorderojavier actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT calvovargasalonso actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT corderovillalobosmaribel actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT chinchillacarmonamisael actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT valeriocamposidalia actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae AT sanchezporrasronald actividadinvitroantileishmaniatrypanosomatidaedelepoxidotranszabisabolenoydelsafrolenfrutosdepiperauritumpiperaceae |
| _version_ |
1810115230656626688 |