Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae)
We tested the effects of the aqueous extract of Petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit and blood glucose level and intestinal motility of male albino NGP mice of 20 to 25 g mean weight. Treatments were in all cases doses of 1 000 and 2 000 mg/kg animal weight and a c...
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Universidad de Costa Rica
2006
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| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/rbt/article/view/3108 |
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RBT31082022-07-06T16:08:13Z Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) García González, Mildred Coto Morales, Teresita Ocampo, Rafael Pazos Sanou, Liliana Petiveria alliacea Phytolaccaceae toxicidad sub-crónica toxicidad aguda motilidad intestinal diabética hierba medicinal medicina tradicional sub-chronic toxicity acute toxicity diabetic intestinal motility herbal medicine traditional medicine We tested the effects of the aqueous extract of Petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit and blood glucose level and intestinal motility of male albino NGP mice of 20 to 25 g mean weight. Treatments were in all cases doses of 1 000 and 2 000 mg/kg animal weight and a control treatment with 0.5 ml distilled water, using 10 animals per treatment and administered orally every day (5 days per week). Experimental periods were 18 and 70 days for acute and sub chronic toxicity, respectively. No mortality nor any toxicity signs could be observed. A slight but significant increase in the glucose levels during the first three weeks was observed with the 1 000 mg/kg dose but not for the higher 2 000 mg/kg dose. After administering the doses once after a starving period of six hours, no significant differences in intestinal motility could be found. We tested the effects of the aqueous extract of Petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit and blood glucose level and intestinal motility of male albino NGP mice of 20 to 25 g mean weight. Treatments were in all cases doses of 1 000 and 2 000 mg/kg animal weight and a control treatment with 0.5 ml distilled water, using 10 animals per treatment and administered orally every day (5 days per week). Experimental periods were 18 and 70 days for acute and sub chronic toxicity, respectively. No mortality nor any toxicity signs could be observed. A slight but significant increase in the glucose levels during the first three weeks was observed with the 1 000 mg/kg dose but not for the higher 2 000 mg/kg dose. After administering the doses once after a starving period of six hours, no significant differences in intestinal motility could be found. Universidad de Costa Rica 2006-12-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article Text application/pdf https://revistas.ucr.ac.cr/index.php/rbt/article/view/3108 10.15517/rbt.v54i4.3108 Revista de Biología Tropical; Vol. 54 No. 4 (2006): Volume 54 – Regular number 4 – December 2006; 1323–1326 Revista de Biología Tropical; Vol. 54 Núm. 4 (2006): Volumen 54 – Número regular 4 – Diciembre 2006; 1323–1326 Revista Biología Tropical; Vol. 54 N.º 4 (2006): Volume 54 – Regular number 4 – December 2006; 1323–1326 2215-2075 0034-7744 10.15517/rbt.v54i4 eng https://revistas.ucr.ac.cr/index.php/rbt/article/view/3108/3016 Copyright (c) 2006 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0 |
| institution |
Universidad de Costa Rica |
| collection |
Revista de Biología Tropical |
| language |
eng |
| format |
Online |
| author |
García González, Mildred Coto Morales, Teresita Ocampo, Rafael Pazos Sanou, Liliana |
| spellingShingle |
García González, Mildred Coto Morales, Teresita Ocampo, Rafael Pazos Sanou, Liliana Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| author_facet |
García González, Mildred Coto Morales, Teresita Ocampo, Rafael Pazos Sanou, Liliana |
| author_sort |
García González, Mildred |
| description |
We tested the effects of the aqueous extract of Petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit and blood glucose level and intestinal motility of male albino NGP mice of 20 to 25 g mean weight. Treatments were in all cases doses of 1 000 and 2 000 mg/kg animal weight and a control treatment with 0.5 ml distilled water, using 10 animals per treatment and administered orally every day (5 days per week). Experimental periods were 18 and 70 days for acute and sub chronic toxicity, respectively. No mortality nor any toxicity signs could be observed. A slight but significant increase in the glucose levels during the first three weeks was observed with the 1 000 mg/kg dose but not for the higher 2 000 mg/kg dose. After administering the doses once after a starving period of six hours, no significant differences in intestinal motility could be found. |
| title |
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| title_short |
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| title_full |
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| title_fullStr |
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| title_full_unstemmed |
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| title_sort |
subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of petiveria alliacea (phytolaccaceae) |
| title_alt |
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae) |
| publisher |
Universidad de Costa Rica |
| publishDate |
2006 |
| url |
https://revistas.ucr.ac.cr/index.php/rbt/article/view/3108 |
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