Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats

A lyophilized aqueous leaf extract of Cecropia obtusifolia proved to be antihypertensive when intravenously administrated to conscious spontaneous hypertensive rats. Forty-five minutes after injection, the maximum fall in arterial pressure (-23.5% relative to preinjection values) was seen and recove...

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Detalles Bibliográficos
Autores principales:	Salas, Isaías, Brenes, J. R., Morales, Orlando M.
Formato:	Online
Idioma:	eng
Publicado:	Universidad de Costa Rica 1987
Acceso en línea:	https://revistas.ucr.ac.cr/index.php/rbt/article/view/24194

id	RBT24194
record_format	ojs
spelling	RBT241942022-05-19T18:27:47Z Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats Salas, Isaías Brenes, J. R. Morales, Orlando M. El extracto crudo liofilizado de Cecropia obtusifolia administrado intravenosamente a ratas espontáneamente hipertensas (SHR), no anestesiadas (50 mg/kg de peso), mostró poseer propiedades antihipertensivas. La presión arterial disminuyó a un mínimo nivel (76.4%) del valor control (161.5 mmHg), 45 minutos después de la inyección. El extracto se administró por infusión a tres grupos de animales: hipertensos, prehipertensos (SHR) y a normotensos (Sprague Dawley). La disminución de la presión arterial fue más evidente en el grupo de ratas hipertensas, siendo estadísticamente significativa en relación a los otros dos grupos (p, 0.05) de acuerdo con el ANOVA y análisis por el método de Tukey.Esta disminución de la presión arterial media (PAM) no fue acompañada por variaciones de la frecuencia cardiaca en ningún grupo, lo cual indica que no hay participación del nodo sinusal directa o indirectamente en la hipotensión observada. A lyophilized aqueous leaf extract of Cecropia obtusifolia proved to be antihypertensive when intravenously administrated to conscious spontaneous hypertensive rats. Forty-five minutes after injection, the maximum fall in arterial pressure (-23.5% relative to preinjection values) was seen and recovery was not complete by the end of the 1 80 min observation periodo The extract was also given to pre-hypertensive SHR and normotensive rats. The fall in blood pressure was more conspicuous in the two SHR groups and was not accompanied by changes in cardiac frequency in any group. This would appear to rule out either a direct or indirect involvement of the heart in regard to the observed hypotension. Universidad de Costa Rica 1987-06-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article application/pdf https://revistas.ucr.ac.cr/index.php/rbt/article/view/24194 Revista de Biología Tropical; Vol. 35 No. 1 (1987): Volume 35 – Regular number 1 – June 1987; 127–130 Revista de Biología Tropical; Vol. 35 Núm. 1 (1987): Volumen 35 – Número regular 1 – Junio 1987; 127–130 Revista Biología Tropical; Vol. 35 N.º 1 (1987): Volume 35 – Regular number 1 – June 1987; 127–130 2215-2075 0034-7744 10.15517/rbt.v35i1 eng https://revistas.ucr.ac.cr/index.php/rbt/article/view/24194/24309 Copyright (c) 1987 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0
institution	Universidad de Costa Rica
collection	Revista de Biología Tropical
language	eng
format	Online
author	Salas, Isaías Brenes, J. R. Morales, Orlando M.
spellingShingle	Salas, Isaías Brenes, J. R. Morales, Orlando M. Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
author_facet	Salas, Isaías Brenes, J. R. Morales, Orlando M.
author_sort	Salas, Isaías
description	A lyophilized aqueous leaf extract of Cecropia obtusifolia proved to be antihypertensive when intravenously administrated to conscious spontaneous hypertensive rats. Forty-five minutes after injection, the maximum fall in arterial pressure (-23.5% relative to preinjection values) was seen and recovery was not complete by the end of the 1 80 min observation periodo The extract was also given to pre-hypertensive SHR and normotensive rats. The fall in blood pressure was more conspicuous in the two SHR groups and was not accompanied by changes in cardiac frequency in any group. This would appear to rule out either a direct or indirect involvement of the heart in regard to the observed hypotension.
title	Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
title_short	Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
title_full	Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
title_fullStr	Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
title_full_unstemmed	Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
title_sort	antihypertensive effect of cecropia obtusifolia (moraceae) leaf extract on rats
title_alt	Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats
publisher	Universidad de Costa Rica
publishDate	1987
url	https://revistas.ucr.ac.cr/index.php/rbt/article/view/24194
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Antihypertensive effect of Cecropia obtusifolia (Moraceae) leaf extract on rats

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