An in vivo model to study the anti-malaric capacity of plant extracts

An in vivo model to study lhe antimalarie ctfeet 01' plant extraets is described. White mi ce (25-30g body weight) are lreated subeutaneously with 0.6ml of the diluted extraet stUlling seven days before P. ber¡:heí infeetion: trealmenl eontinlles lIntil death or for 30 days. Simultaneously 0.2m...

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Detalles Bibliográficos
Autores principales: Chinchilla, Misael, Guerrero, Olga M, Abarca, Gabriela, Barrios, Mario, Castro, Oscar
Formato: Online
Idioma:eng
Publicado: Universidad de Costa Rica 1998
Acceso en línea:https://revistas.ucr.ac.cr/index.php/rbt/article/view/19350
Descripción
Sumario:An in vivo model to study lhe antimalarie ctfeet 01' plant extraets is described. White mi ce (25-30g body weight) are lreated subeutaneously with 0.6ml of the diluted extraet stUlling seven days before P. ber¡:heí infeetion: trealmenl eontinlles lIntil death or for 30 days. Simultaneously 0.2ml of the extraet are applied per os stming three days befare infection. In a test 01' the model, treated and non-treated animals differed in body weight, survival time, haematocrite, parnsitemia development, and spleen or liver weight of recent dcad 01' killed mice.