Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)

Infection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differenc...

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Autores principales:	Minero, Miguel Angel, Chinchilla, Misael, Guerrero, Olga Marta, Castro, Alfredo
Formato:	Online
Idioma:	spa
Publicado:	Universidad de Costa Rica 2004
Acceso en línea:	https://revistas.ucr.ac.cr/index.php/rbt/article/view/14942

id	RBT14942
record_format	ojs
spelling	RBT149422022-05-30T17:28:15Z Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae) Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae) Minero, Miguel Angel Chinchilla, Misael Guerrero, Olga Marta Castro, Alfredo Infection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differences in the cells from these rodent species were determined, for L. infantum as well as for L. mexicana. Parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to Leishmania infection. These results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. On the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. Therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals. Infection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differences in the cells from these rodent species were determined, for L. infantum as well as for L. mexicana. Parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to Leishmania infection. These results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. On the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. Therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals. Universidad de Costa Rica 2004-03-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion application/pdf https://revistas.ucr.ac.cr/index.php/rbt/article/view/14942 Revista de Biología Tropical; Vol. 52 No. 1 (2004): Volume 52 – Regular number 1 – March 2004; 261–267 Revista de Biología Tropical; Vol. 52 Núm. 1 (2004): Volumen 52 – Número regular 1 – Marzo 2004; 261–267 Revista Biología Tropical; Vol. 52 N.º 1 (2004): Volume 52 – Regular number 1 – March 2004; 261–267 2215-2075 0034-7744 10.15517/rbt.v52i1 spa https://revistas.ucr.ac.cr/index.php/rbt/article/view/14942/14208 Copyright (c) 2004 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0
institution	Universidad de Costa Rica
collection	Revista de Biología Tropical
language	spa
format	Online
author	Minero, Miguel Angel Chinchilla, Misael Guerrero, Olga Marta Castro, Alfredo
spellingShingle	Minero, Miguel Angel Chinchilla, Misael Guerrero, Olga Marta Castro, Alfredo Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
author_facet	Minero, Miguel Angel Chinchilla, Misael Guerrero, Olga Marta Castro, Alfredo
author_sort	Minero, Miguel Angel
description	Infection and multiplication of Leishmania infantum and L. mexicana inside of skin fibroblasts from hamsters, mice and rats was achieved. This process was demonstrated either by counting parasites inside the stained cells or by electronic microscopy studies. In addition multiplication rate differences in the cells from these rodent species were determined, for L. infantum as well as for L. mexicana. Parasite development in hamsters and mice fibroblasts was evident but there was not multiplication in rat cells showing that apparently they are refractory to Leishmania infection. These results suggest that the parasite affinity for each animal, as well as any intracellular environment resistance, could involve genetic factors in the parasite multiplication. On the other hand, presence of amastigote multiplication inside of parasitophorus vacuole, showed by electronic microscopy images, probes a true parasite transformation. Therefore it is suggested that fibroblasts could work as host cells for parasite survival and permanency in the infected animals.
title	Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
title_short	Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
title_full	Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
title_fullStr	Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
title_full_unstemmed	Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
title_sort	infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a leishmania infantum y leishmania mexicana (kinetoplastida: trypanosomatidae)
title_alt	Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)
publisher	Universidad de Costa Rica
publishDate	2004
url	https://revistas.ucr.ac.cr/index.php/rbt/article/view/14942
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Infección de fibroblastos de piel de animales con distinto grado de susceptibilidad a Leishmania infantum y Leishmania mexicana (Kinetoplastida: Trypanosomatidae)

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