Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

CYP2D6 differences have already been demonstrated within Latin American populations by the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics (RIBEF, as per the acronym in Spanish). However, within the population of Costa Rica, no research has been conducted until now, even though...

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Autores principales:	Céspedes-Garro, Carolina, Jiménez-Arce, Gerardo, Naranjo, María-Eugenia G., Barrantes, Ramiro, LLerena, Adrián, institucional, Autor
Formato:	Online
Idioma:	eng spa
Publicado:	Universidad de Costa Rica 2014
Acceso en línea:	https://revistas.ucr.ac.cr/index.php/rbt/article/view/12916

id	RBT12916
record_format	ojs
spelling	RBT129162022-06-09T17:30:45Z Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans Céspedes-Garro, Carolina Jiménez-Arce, Gerardo Naranjo, María-Eugenia G. Barrantes, Ramiro LLerena, Adrián institucional, Autor CYP2D6 Costa Rica Amerindian Afro-Caribbean mestizo populations Poor Metabolizers Ultra-rapid Metabolizers CYP2D6 differences have already been demonstrated within Latin American populations by the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics (RIBEF, as per the acronym in Spanish). However, within the population of Costa Rica, no research has been conducted until now, even though this population has a trihybrid component ancestry that represents an interesting condition. Thus, the present study was aimed to determine the frequency of Ultra-rapid Metabolizers (UMs) and Poor Metabolizers (PMs) in a Costa Rican population, as well as to determine whether there are differences in the CYP2D6-predicted phenotype frequencies among three Costa Rican groups with different ethnic backgrounds. Additionally, these frequencies of PMs and UMs obtained were compared with Ibero-American populations published data. Finally, we also aimed to describe allele frequencies among different Costa Rican ethnic groups. This research has been undertaken within the framework of the RIBEF CEIBA Consortium studies on Latin American populations. A total of 385 individuals were included in the study: 139 mestizos, 197 Amerindians, and 49 Afro-Caribbeans. CYP2D6 genotypes were determined by XL-PCR and Real-Time PCR. The CYP2D6 variant alleles 2, 3, 4, 5, 6, 10, 17, 29, 35 and 41 were also determined. For the entire Costa Rican population, the frequency of PMs and UMs was 6% and 6.5%, respectively. The percentage of UMs in the mestizo population was higher than in the Amerindian population. CYP2D6 UMs vary from 3.6% to 10.1% and PMs from 1.4% to 10.2% among three Costa Rican groups. The highest frequencies of UMs (10.1%) and PMs (10.2%) were found in the mestizo and Amerindian populations, respectively. In conclusion, the frequencies of UMs and PMs for CYP2D6 varied widely across the mestizo, Amerindian and Afro-Caribbean Costa Rican populations. Future research in this population should be oriented to identify new CYP2D6 variants through sequencing methods, as well as to determine CYP2D6 phenotype, in order to establish the phenotype-genotype relation. Finally, further studies involving genetic markers of ancestry are needed in the Costa Rican population. Carolina Céspedes-Garro1,2, Gerardo Jiménez-Arce1, María-Eugenia G. Naranjo2, Ramiro Barrantes1* and Adrián LLerena2*; CEIBA Consortium of the Ibero-American Network of Pharmacogenetics & Pharmacogenomics RIBEF. Universidad de Costa Rica 2014-12-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Contribution application/pdf text/html https://revistas.ucr.ac.cr/index.php/rbt/article/view/12916 10.15517/rbt.v62i4.12916 Revista de Biología Tropical; Vol. 62 No. 4 (2014): Volume 62 – Regular number 4 – December 2014; 1659–1671 Revista de Biología Tropical; Vol. 62 Núm. 4 (2014): Volumen 62 – Número regular 4 – Diciembre 2014; 1659–1671 Revista Biología Tropical; Vol. 62 N.º 4 (2014): Volume 62 – Regular number 4 – December 2014; 1659–1671 2215-2075 0034-7744 10.15517/rbt.v62i4 eng spa https://revistas.ucr.ac.cr/index.php/rbt/article/view/12916/15532 https://revistas.ucr.ac.cr/index.php/rbt/article/view/12916/15533 Copyright (c) 2014 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0
institution	Universidad de Costa Rica
collection	Revista de Biología Tropical
language	eng spa
format	Online
author	Céspedes-Garro, Carolina Jiménez-Arce, Gerardo Naranjo, María-Eugenia G. Barrantes, Ramiro LLerena, Adrián institucional, Autor
spellingShingle	Céspedes-Garro, Carolina Jiménez-Arce, Gerardo Naranjo, María-Eugenia G. Barrantes, Ramiro LLerena, Adrián institucional, Autor Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans
author_facet	Céspedes-Garro, Carolina Jiménez-Arce, Gerardo Naranjo, María-Eugenia G. Barrantes, Ramiro LLerena, Adrián institucional, Autor
author_sort	Céspedes-Garro, Carolina
description	CYP2D6 differences have already been demonstrated within Latin American populations by the CEIBA.FP Consortium of the Ibero-American Network of Pharmacogenetics (RIBEF, as per the acronym in Spanish). However, within the population of Costa Rica, no research has been conducted until now, even though this population has a trihybrid component ancestry that represents an interesting condition. Thus, the present study was aimed to determine the frequency of Ultra-rapid Metabolizers (UMs) and Poor Metabolizers (PMs) in a Costa Rican population, as well as to determine whether there are differences in the CYP2D6-predicted phenotype frequencies among three Costa Rican groups with different ethnic backgrounds. Additionally, these frequencies of PMs and UMs obtained were compared with Ibero-American populations published data. Finally, we also aimed to describe allele frequencies among different Costa Rican ethnic groups. This research has been undertaken within the framework of the RIBEF CEIBA Consortium studies on Latin American populations. A total of 385 individuals were included in the study: 139 mestizos, 197 Amerindians, and 49 Afro-Caribbeans. CYP2D6 genotypes were determined by XL-PCR and Real-Time PCR. The CYP2D6 variant alleles 2, 3, 4, 5, 6, 10, 17, 29, 35 and 41 were also determined. For the entire Costa Rican population, the frequency of PMs and UMs was 6% and 6.5%, respectively. The percentage of UMs in the mestizo population was higher than in the Amerindian population. CYP2D6 UMs vary from 3.6% to 10.1% and PMs from 1.4% to 10.2% among three Costa Rican groups. The highest frequencies of UMs (10.1%) and PMs (10.2%) were found in the mestizo and Amerindian populations, respectively. In conclusion, the frequencies of UMs and PMs for CYP2D6 varied widely across the mestizo, Amerindian and Afro-Caribbean Costa Rican populations. Future research in this population should be oriented to identify new CYP2D6 variants through sequencing methods, as well as to determine CYP2D6 phenotype, in order to establish the phenotype-genotype relation. Finally, further studies involving genetic markers of ancestry are needed in the Costa Rican population. Carolina Céspedes-Garro1,2, Gerardo Jiménez-Arce1, María-Eugenia G. Naranjo2, Ramiro Barrantes1* and Adrián LLerena2*; CEIBA Consortium of the Ibero-American Network of Pharmacogenetics & Pharmacogenomics RIBEF.
title	Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans
title_short	Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans
title_full	Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans
title_fullStr	Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans
title_full_unstemmed	Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans
title_sort	ethnic background and cyp2d6 genetic polymorphisms in costa ricans
publisher	Universidad de Costa Rica
publishDate	2014
url	https://revistas.ucr.ac.cr/index.php/rbt/article/view/12916
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_version_	1810114634570530816

Ethnic background and CYP2D6 genetic polymorphisms in Costa Ricans

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