Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis
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| Formato: | Online |
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Universidad de Costa Rica
2017
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| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/Odontos/article/view/28915 |
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ODONTOS28915 |
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ODONTOS289152021-06-09T00:13:57Z Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis González Quesada DDS, MSc, Jorge Vidal Soto Phd, Rodrigo Fuentes Zuleta DDS, MSc, Patricio Genetic polymorphism Chronic periodontitis Aggressive periodontitis The multifactorial etiology of periodontitis is recognized, where genetic and environmental factors interact to produce the disease and modify its clinical expression The aim of this study is to determine the association between the presence of the polymorphism for IgG subclass III A receptor (FCYRIIIA-158V-F) and severe periodontitis. Materials and Methods: The study sample was composed of 150 patients: 32 patients with aggressive periodontitis, 71 patients with chronic periodontitis, and 47 clinically healthy volunteers without periodontitis. Peripheral blood samples, approximately 20μl, were obtained. DNA extraction was carried out from the FTAelute micro-cards. The selected polymorphisms were amplified by PCR. Results: The genotypic frequencies of the three groups evaluated met the Hardy-Weinberg equilibrium (Chi-square test, p-value> 0.05, 95% CI). The difference between the periodontitis (chronic and aggressive peridontitis) group and the group of healthy individuals was statistically significant for the presence of the T allele (p≤0.004), with an OR of 4.03 (95% CI), the sensitivity to 93% and specificity to 23%, with a positive predictive value of 72% and a negative predictive value of 61%. Conclusions: A statistically significant association was found between the presence of the T allele in the polymorphism of FCYRIIIA-158V-F and the diseased condition (periodontitis group), suggesting that the T allele possesses a higher probability of developing severe periodontitis. Due to the importance of identifying subjects susceptible to periodontitis we recommend further studies. Universidad de Costa Rica 2017-05-12 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article clinical research application/pdf text/html https://revistas.ucr.ac.cr/index.php/Odontos/article/view/28915 10.15517/ijds.v19i2.28915 Odovtos - International Journal of Dental Sciences; Vol. 19 No. 2 (2017): (May-August) Odovtos-International Journal of Dental Sciences; 79-88 Odovtos International Journal of Dental Sciences; Vol. 19 Núm. 2 (2017): (May-August) Odovtos-International Journal of Dental Sciences; 79-88 2215-3411 1659-1046 10.15517/ijds.v19i2 eng https://revistas.ucr.ac.cr/index.php/Odontos/article/view/28915/28958 https://revistas.ucr.ac.cr/index.php/Odontos/article/view/28915/29203 Copyright (c) 2017 Odovtos - International Journal of Dental Sciences |
| institution |
Universidad de Costa Rica |
| collection |
Odovtos International Journal of Dental Sciences |
| language |
eng |
| format |
Online |
| author |
González Quesada DDS, MSc, Jorge Vidal Soto Phd, Rodrigo Fuentes Zuleta DDS, MSc, Patricio |
| spellingShingle |
González Quesada DDS, MSc, Jorge Vidal Soto Phd, Rodrigo Fuentes Zuleta DDS, MSc, Patricio Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis |
| author_facet |
González Quesada DDS, MSc, Jorge Vidal Soto Phd, Rodrigo Fuentes Zuleta DDS, MSc, Patricio |
| author_sort |
González Quesada DDS, MSc, Jorge |
| title |
Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis |
| title_short |
Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis |
| title_full |
Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis |
| title_fullStr |
Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis |
| title_full_unstemmed |
Association Between the FCYRIIIA-158V-F Polymorphism and Periodontitis |
| title_sort |
association between the fcyriiia-158v-f polymorphism and periodontitis |
| publisher |
Universidad de Costa Rica |
| publishDate |
2017 |
| url |
https://revistas.ucr.ac.cr/index.php/Odontos/article/view/28915 |
| work_keys_str_mv |
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