Histomorphometric Evaluation of Elastosis in Actinic Cheilitis
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| Formato: | Online |
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Universidad de Costa Rica
2016
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| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/Odontos/article/view/26496 |
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ODONTOS26496 |
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ODONTOS264962017-01-19T19:20:43Z Histomorphometric Evaluation of Elastosis in Actinic Cheilitis Boza Oreamuno DDS, MSc, Yadira V. Martínez DDS, Alejandra Rojas DDS, PhD, Isolde G. Actinic cheilitis Actinic elastosis Elastin fibers Collagen fibers Photodamage Actinic cheilitis (AC) is a potentially malignant lesion of the lip characterized by basophilic degeneration of the extracellular matrix (ECM) as a result of chronic exposure to sunlight. This alteration, known as actinic elastosis, has not been previously characterized by histomorphometry in AC and normal lip tissues (NL). METHODS: Formalin-fixed and paraffin-embedded samples of AC (n=33) and NL (n=16) obtained from the Archives of the College of Dentistry of the University of Concepción, were stained with Verhoeff-Van Giesson technique. Elastic fibers were characterized and quantified by histomorphometry using Image J Program (NIH Image). RESULTS: In AC, elastin fibers were disorganized and increased in thickness and collagen fibers looked degenerated. A significant increase in elastin fibers was found in AC as compared to NL (p<0.05). The ratio between elastin/collagen fibers was also higher in AC than NL (p<0.02). However, collagen fiber density was similar between AC and NL. A negative correlation between elastic and collagen fibers was found in AC (p<0.0001, r=0.6). Conclusions: Using histomorphometry we found a significant difference in the composition of the ECM in AC as compared to NL. This difference was mainly due to the increase in elastin fiber content in AC. Universidad de Costa Rica 2016-10-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article Original clinical reseach application/pdf text/html https://revistas.ucr.ac.cr/index.php/Odontos/article/view/26496 10.15517/ijds.v0i0.26496 Odovtos - International Journal of Dental Sciences; Vol. 18 No. 3 (2016): Odovtos - International Journal of Dental Sciences V.3 (September-December)-2016; 51-59 Odovtos International Journal of Dental Sciences; Vol. 18 Núm. 3 (2016): Odovtos - International Journal of Dental Sciences V.3 (September-December)-2016; 51-59 2215-3411 1659-1046 10.15517/ijds.v18i3 eng https://revistas.ucr.ac.cr/index.php/Odontos/article/view/26496/26726 https://revistas.ucr.ac.cr/index.php/Odontos/article/view/26496/27972 Copyright (c) 2016 Odovtos - International Journal of Dental Sciences |
| institution |
Universidad de Costa Rica |
| collection |
Odovtos International Journal of Dental Sciences |
| language |
eng |
| format |
Online |
| author |
Boza Oreamuno DDS, MSc, Yadira V. Martínez DDS, Alejandra Rojas DDS, PhD, Isolde G. |
| spellingShingle |
Boza Oreamuno DDS, MSc, Yadira V. Martínez DDS, Alejandra Rojas DDS, PhD, Isolde G. Histomorphometric Evaluation of Elastosis in Actinic Cheilitis |
| author_facet |
Boza Oreamuno DDS, MSc, Yadira V. Martínez DDS, Alejandra Rojas DDS, PhD, Isolde G. |
| author_sort |
Boza Oreamuno DDS, MSc, Yadira V. |
| title |
Histomorphometric Evaluation of Elastosis in Actinic Cheilitis |
| title_short |
Histomorphometric Evaluation of Elastosis in Actinic Cheilitis |
| title_full |
Histomorphometric Evaluation of Elastosis in Actinic Cheilitis |
| title_fullStr |
Histomorphometric Evaluation of Elastosis in Actinic Cheilitis |
| title_full_unstemmed |
Histomorphometric Evaluation of Elastosis in Actinic Cheilitis |
| title_sort |
histomorphometric evaluation of elastosis in actinic cheilitis |
| publisher |
Universidad de Costa Rica |
| publishDate |
2016 |
| url |
https://revistas.ucr.ac.cr/index.php/Odontos/article/view/26496 |
| work_keys_str_mv |
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