Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models
Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight...
| Autores principales: | , , |
|---|---|
| Formato: | Online |
| Idioma: | eng |
| Publicado: |
Universidad de Costa Rica
2009
|
| Acceso en línea: | https://revistas.ucr.ac.cr/index.php/rbt/article/view/5456 |
| id |
RBT5456 |
|---|---|
| record_format |
ojs |
| spelling |
RBT54562022-06-06T18:20:04Z Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models Adedapo, Adeolu A. Sofidiya, Margaret O. Afolayan, Anthony J. analgésico antiinflamatorio carragenina histamina indometacina Margaritaria discoidea ratas analgesic anti-inflammatory carrageenan histamine indomethacin extract rats Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations. Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations. Universidad de Costa Rica 2009-12-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article Text application/pdf https://revistas.ucr.ac.cr/index.php/rbt/article/view/5456 10.15517/rbt.v57i4.5456 Revista de Biología Tropical; Vol. 57 No. 4 (2009): Volume 57 – Regular number 4 – December 2009; 1193–1200 Revista de Biología Tropical; Vol. 57 Núm. 4 (2009): Volumen 57 – Número regular 4 – Diciembre 2009; 1193–1200 Revista Biología Tropical; Vol. 57 N.º 4 (2009): Volume 57 – Regular number 4 – December 2009; 1193–1200 2215-2075 0034-7744 10.15517/rbt.v57i4 eng https://revistas.ucr.ac.cr/index.php/rbt/article/view/5456/5202 Copyright (c) 2009 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0 |
| institution |
Universidad de Costa Rica |
| collection |
Revista de Biología Tropical |
| language |
eng |
| format |
Online |
| author |
Adedapo, Adeolu A. Sofidiya, Margaret O. Afolayan, Anthony J. |
| spellingShingle |
Adedapo, Adeolu A. Sofidiya, Margaret O. Afolayan, Anthony J. Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| author_facet |
Adedapo, Adeolu A. Sofidiya, Margaret O. Afolayan, Anthony J. |
| author_sort |
Adedapo, Adeolu A. |
| description |
Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations. |
| title |
Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| title_short |
Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| title_full |
Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| title_fullStr |
Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| title_full_unstemmed |
Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| title_sort |
anti-inflammatory and analgesic activities of the aqueous extracts of margaritaria discoidea (euphorbiaceae) stem bark in experimental animal models |
| title_alt |
Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models |
| publisher |
Universidad de Costa Rica |
| publishDate |
2009 |
| url |
https://revistas.ucr.ac.cr/index.php/rbt/article/view/5456 |
| work_keys_str_mv |
AT adedapoadeolua antiinflammatoryandanalgesicactivitiesoftheaqueousextractsofmargaritariadiscoideaeuphorbiaceaestembarkinexperimentalanimalmodels AT sofidiyamargareto antiinflammatoryandanalgesicactivitiesoftheaqueousextractsofmargaritariadiscoideaeuphorbiaceaestembarkinexperimentalanimalmodels AT afolayananthonyj antiinflammatoryandanalgesicactivitiesoftheaqueousextractsofmargaritariadiscoideaeuphorbiaceaestembarkinexperimentalanimalmodels |
| _version_ |
1810114542460469248 |