Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats

On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), w...

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Main Authors:	Badilla, Beatriz, Mora, Gerardo, Lapa, Antonio José, Silva Ernim, José Arthur
Format:	Online
Language:	eng
Published:	Universidad de Costa Rica 1999
Online Access:	https://revistas.ucr.ac.cr/index.php/rbt/article/view/19085

id	RBT19085
record_format	ojs
spelling	RBT190852022-05-25T21:18:11Z Anti-inflarnmatory activity of Urera baccifera (Urticaceae) in Sprague-Dawley rats Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats Badilla, Beatriz Mora, Gerardo Lapa, Antonio José Silva Ernim, José Arthur urera baccifera anti-illflammatory agent analgesic antinociceptive rat paw edema urticaceae On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level. On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level. Universidad de Costa Rica 1999-09-01 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article application/pdf https://revistas.ucr.ac.cr/index.php/rbt/article/view/19085 10.15517/rbt.v47i3.19085 Revista de Biología Tropical; Vol. 47 No. 3 (1999): Volume 47 – Regular number 3 – September 1999; 365–371 Revista de Biología Tropical; Vol. 47 Núm. 3 (1999): Volumen 47 – Volumen regular 3 – Setiembre 1999; 365–371 Revista Biología Tropical; Vol. 47 N.º 3 (1999): Volume 47 – Regular number 3 – September 1999; 365–371 2215-2075 0034-7744 eng https://revistas.ucr.ac.cr/index.php/rbt/article/view/19085/19167 Copyright (c) 1999 Revista de Biología Tropical http://creativecommons.org/licenses/by/4.0
institution	Universidad de Costa Rica
collection	Revista de Biología Tropical
language	eng
format	Online
author	Badilla, Beatriz Mora, Gerardo Lapa, Antonio José Silva Ernim, José Arthur
spellingShingle	Badilla, Beatriz Mora, Gerardo Lapa, Antonio José Silva Ernim, José Arthur Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats
author_facet	Badilla, Beatriz Mora, Gerardo Lapa, Antonio José Silva Ernim, José Arthur
author_sort	Badilla, Beatriz
description	On a preliminary test, anti-inflammatory and analgesic dose-related activities on rats were observed for the aqueous fraction of Urera baccifera; this extract was bioassay-guided fractionated and the final aqueous fraction was used according the ethnobotanical use. Carrageenan-induced edema (n=6), was used as an assay in the fractionating process. The anti-inflammatory and antinociceptive properties of the final aqueons fraction were studied using in vivo models. For the anti-inflammatory activity rat paw edema (n=6), pleurisy induced by carrageenan (n=6) and ear edema induced by topical croton oil (n=6) models were used, and tail-fIick test (n=6), abdominal constrictions induced by acetic acid (n=6), and formalin test (n=6), were used for the alltillociceptive activity. The tests perfonned showed an inhibition effeet on !eukocyte rnigration, and a reductioll on pleural exudate, as well as dose-dependant peripheral analgesic activity, al a range of 25-100 mglk:g i.p. The final aqueous fraction contains most of the anti-inflammatory activity of the plant U. baccifera. A possibJe mechanism of action is discussed and based on the results we conclude that this plant has a potential. for both anti-inflammalory and analgesic activity al the c1inical level.
title	Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats
title_short	Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats
title_full	Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats
title_fullStr	Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats
title_full_unstemmed	Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats
title_sort	anti-inflarnmatory activity of urera baccifera(urticaceae) in sprague-dawley rats
title_alt	Anti-inflarnmatory activity of Urera baccifera (Urticaceae) in Sprague-Dawley rats
publisher	Universidad de Costa Rica
publishDate	1999
url	https://revistas.ucr.ac.cr/index.php/rbt/article/view/19085
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_version_	1810114775326130176

Anti-inflarnmatory activity of Urera baccifera(Urticaceae) in Sprague-Dawley rats

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